DSpace
 

DSpace at IIT Bombay >
IITB Publications >
Article >

Please use this identifier to cite or link to this item: http://dspace.library.iitb.ac.in/jspui/handle/10054/11463

Title: Technetium-99m-cyclam AK 2123: a novel marker for tumor hypoxia
Authors: MURUGESAN, S
SHETTY, SJ
NORONHA, OPD
SAMUEL, AM
SRIVASTAVA, TS
NAIR, CKK
KOTHARI, L
Keywords: positron emission tomography
iodoazomycin arabinoside
f-18 fluoromisonidazole
imaging agent
bms181321
tissue
Issue Date: 2001
Publisher: PERGAMON-ELSEVIER SCIENCE LTD
Citation: APPLIED RADIATION AND ISOTOPES, 54(1), 81-88
Abstract: Technetium-99m labeled cyclam N-2'-methoxyethyl-2-(3'-nitro-1'-triazole) acetamide (cyclam AK 2123) has been synthesized, radiolabeled and characterized as a hypoxic tumor imaging agent. Radiochemical purity was greater than 95%. Marker biodistribution was measured in normal Wistar strain rats at different time intervals after intra venous (i.v.) administration. In vivo distribution and scintigraphic imaging studies were performed after i.v. injection into mammary tumor-bearing rats using a gamma camera and associated computer. Intratumor partial oxygen pressure (pO(2)) and oxygen saturation measurements were performed to estimate the oxygenation status of the tumors. Tumor to muscle ratio (T/M) of Tc-99m-cyclam AK 2123 was 8.5 which was compared with other tumor seeking radiopharmaceuticals, viz. Tc-99m-(V) DMSA (3.07), Tc-99m-citrate (5.29) and (201)T1C1 (3.29). T/M ratios were also evaluated in comparison with radioiodinated iodoazomycin galactopyronoside (I-125-IAZG). The ratio obtained was 18 for Tc-99m-cyclam AK 2123 and 20 for I-125-IAZG, respectively. The increased concentration of radioactivity in these tumors suggests that this agent could be labelling hypoxic cells and have utility as an imaging agent. (. .
URI: http://dx.doi.org/10.1016/S0969-8043(00)00104-4
http://dspace.library.iitb.ac.in/xmlui/handle/10054/11463
http://hdl.handle.net/10054/11463
ISSN: 0969-8043
Appears in Collections:Article

Files in This Item:

There are no files associated with this item.

View Statistics

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

 

Valid XHTML 1.0! DSpace Software Copyright © 2002-2010  Duraspace - Feedback