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Please use this identifier to cite or link to this item: http://dspace.library.iitb.ac.in/jspui/handle/10054/11449

Title: Synthesis of potential pregnenolone and progesterone spin probes for biomembranes and immunoassays
Authors: KATOCH, R
KORDE, SS
DEODHAR, KD
TRIVEDI, GK
Keywords: 2,3 sigmatropic rearrangement
stereospecific synthesis
lithocholic acid
model membranes
2'-(3-alpha-benzyloxy-24-norcholan-23-yl)-2',4',4'-trimethyl-4',5'-dihydrooxazo.
nitroxides
reduction
steroids
Issue Date: 1999
Publisher: PERGAMON-ELSEVIER SCIENCE LTD
Citation: TETRAHEDRON, 55(6), 1741-1754
Abstract: The synthesis and characterization of four new steroidal spin labels, viz., 3'-[[(pregn-5-en-3 beta-ol-20S-yl)methyl]oate]- 2',2',5',5'-tetramethylpyrrolidine-1'-oxyl,3'-[[(pregn-4-en-3- one-20S-yl)methyl]oate]-2',2',5'.5'-tetra methyl pyrrolidine-1'-oxyl, 3 "[(3 beta-acetoxypregn-5-en-20-one-16 alpha-yl)prop-2'xi-ol-3'xi-oate]-2 ",2 ",5 ",5 "-tetramethyl pyrrolidine-1 "-oxyl and 3 "-[(pregn-5-en-3,20-dione-16 alpha-yl)prop-2'xi-ol-3'xi-oate]-2',2',5',5'-tetramethylpyrrolidine-1'-oxyl has been described which involves functionalization of the parent hormone at C-20 and C-16. The key step to all the products was the condensation of 3-carboxyproxyl with the derivatized synthons. (C) 1999 . .
URI: http://dx.doi.org/10.1016/S0040-4020(98)01187-9
http://dspace.library.iitb.ac.in/xmlui/handle/10054/11449
http://hdl.handle.net/10054/11449
ISSN: 0040-4020
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