DSpace
 

DSpace at IIT Bombay >
IITB Publications >
Article >

Please use this identifier to cite or link to this item: http://dspace.library.iitb.ac.in/jspui/handle/10054/10703

Title: Design, synthesis and biological evaluation of novel riccardiphenol analogs
Authors: KUMAR, SK
AMADOR, M
HIDALGO, M
BHAT, SV
KHAN, SR
Keywords: liverwort bazzania-tridens
absolute-configuration
lithiation reactions
convenient synthesis
new-zealand
key step
alkylation
hydroquinones
3-sulfolenes
terpenoids
Issue Date: 2005
Publisher: PERGAMON-ELSEVIER SCIENCE LTD
Citation: BIOORGANIC & MEDICINAL CHEMISTRY, 13(8), 2873-2880
Abstract: A novel, facile, high yield, and less cumbersome synthesis of riccardiphenol, analogs is described. The synthesized compounds were characterized and assessed for its in vitro activity in a panel of human cancer cell lines of differing origin: HuCCT-1, BxPC3, Panc-1, Mia-Paca, A431, Hep2, and HN006. HuCCT-1 was derived from an intrahepatic cholangiocarcinoma; BxPC3, Mia-Paca, and Panc-1 were derived from pancreatic cancers; A431 was derived from a vulvar epithelial carcinoma; and Hep2 and HN006 were derived from squamous cell carcinomas of the head and neck. The cytotoxicity of a newly developed riccardiphenol analog against human cancer cell lines was assessed. The cancer cells exhibited varying sensitivities to the compound, with IC50 values from 30 to 50 mu M. This susceptibility was particularly interesting in the case of lines such as Hep2 and BxPC3 that are resistant to classic cytotoxic drugs as well as some targeted agents. These results demonstrate that the novel riccardiphenol analog has effective action against human-derived cancer cell in vitro. (c) 2005
URI: http://dx.doi.org/10.1016/j.bmc.2005.02.010
http://dspace.library.iitb.ac.in/xmlui/handle/10054/10703
http://hdl.handle.net/10054/10703
ISSN: 0968-0896
Appears in Collections:Article

Files in This Item:

There are no files associated with this item.

View Statistics

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

 

Valid XHTML 1.0! DSpace Software Copyright © 2002-2010  Duraspace - Feedback