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Please use this identifier to cite or link to this item: http://dspace.library.iitb.ac.in/jspui/handle/10054/10545

Title: Antimalarial t-butylperoxyamines
Authors: SUNDAR, N
JACOB, VT
BHAT, SV
VALECHA, N
BISWAS, S
Keywords: potential antimalarials
qinghaosu artemisinin
malaria parasites
peroxide
derivatives
chemistry
Issue Date: 2001
Publisher: PERGAMON-ELSEVIER SCIENCE LTD
Citation: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 11(17), 2269-2272
Abstract: Twelve t-butylperoxyamines (6 17) were synthesized as targeted antimalarials and evaluated for antimalarial activity in vivo against Plasmodium berghei in mice and in vitro against both chloroquine sensitive and chloroquine resistant strains of Plasmodium falciparum. Compound 8 was found to have highest potency with activity at 80 and 160 mg/kg dose in vivo and compound I I exhibited highest efficacy in vitro. (C) 2001 . .
URI: http://dx.doi.org/10.1016/S0960-894X(01)00396-1
http://dspace.library.iitb.ac.in/xmlui/handle/10054/10545
http://hdl.handle.net/10054/10545
ISSN: 0960-894X
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