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|Publisher:||PERGAMON-ELSEVIER SCIENCE LTD|
|Citation:||BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 11(17), 2269-2272|
|Abstract:||Twelve t-butylperoxyamines (6 17) were synthesized as targeted antimalarials and evaluated for antimalarial activity in vivo against Plasmodium berghei in mice and in vitro against both chloroquine sensitive and chloroquine resistant strains of Plasmodium falciparum. Compound 8 was found to have highest potency with activity at 80 and 160 mg/kg dose in vivo and compound I I exhibited highest efficacy in vitro. (C) 2001 . .|
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