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|Title: ||Antimalarial activity of 3-hydroxyalkyl-2-methylenepropionic acid derivatives|
|Authors: ||KUNDU, MK|
|Keywords: ||baylis-hillman reaction|
|Issue Date: ||1999|
|Publisher: ||PERGAMON-ELSEVIER SCIENCE LTD|
|Citation: ||BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 9(5), 731-736|
|Abstract: ||Several Baylis-Hillman adducts and their derivatives were synthesized and evaluated as targeted potential anti-malarials, The compounds 4, 7 and 9 were found to have highest potency against P. falciparum in vitro. The in vivo test result of compound 4 and 9 against P. berghei demonstrated activity at 80 mg/Kg dose level. (C) 1999 . .|
|Appears in Collections:||Article|
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