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| Title: | Antimalarial activity of 3-hydroxyalkyl-2-methylenepropionic acid derivatives |
| Authors: | KUNDU, MK
SUNDAR, N
KUMAR, SK
BHAT, SV
BISWAS, S
VALECHA, N |
| Keywords: | baylis-hillman reaction |
| Issue Date: | 1999 |
| Publisher: | PERGAMON-ELSEVIER SCIENCE LTD |
| Citation: | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 9(5), 731-736 |
| Abstract: | Several Baylis-Hillman adducts and their derivatives were synthesized and evaluated as targeted potential anti-malarials, The compounds 4, 7 and 9 were found to have highest potency against P. falciparum in vitro. The in vivo test result of compound 4 and 9 against P. berghei demonstrated activity at 80 mg/Kg dose level. (C) 1999 . . |
| URI: | http://dx.doi.org/10.1016/S0960-894X(99)00057-8
http://dspace.library.iitb.ac.in/xmlui/handle/10054/10544
http://hdl.handle.net/10054/10544 |
| ISSN: | 0960-894X |
| Appears in Collections: | Article
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