DSpace
 

DSpace at IIT Bombay >
IITB Publications >
Article >

Please use this identifier to cite or link to this item: http://dspace.library.iitb.ac.in/jspui/handle/10054/10485

Title: A technetium-99m-labelled cyclam acid porphyrin (CAP) for tumour imaging
Authors: MURUGESAN, S
SHETTY, SJ
SRIVASTAVA, TS
NORONHA, OPD
SAMUEL, AM
Keywords: photodynamic therapy
metal-complexes
radiopharmaceuticals
photosensitizers
technetium
medicine
model
Issue Date: 2001
Publisher: PERGAMON-ELSEVIER SCIENCE LTD
Citation: APPLIED RADIATION AND ISOTOPES, 55(5), 641-646
Abstract: A new water-soluble cyclam acid porphyrin (CAP), 5,10,15,20-tetrakis- [4-{4',8',11'-tris(carboxymethyl)-1'-(1',4',8',11'-tetraazacyclotetradecane)amidomethyleneoxy} phenyl] porphyrin has been synthesised, characterised and labelled with Tc-99m. In vivo distribution studies were performed in C-6-gliomas and N-nitroso-N-methylurea (NMU) induced mammary tumour bearing rats and scintiimages were obtained at 5 h post-administration of the labelled ligand using gamma camera computer system. Tumour to muscle (T/M) ratios were determined and compared with currently available tumour seeking radiopharmaceuticals such as Tc-99m(V)-DMSA, Tc-99m-Citrate and (TlCl)-Tl-201. In the case of NMU induced mammary tumour rats the ratios were 6.93, 1.97, 5.30 and 3.29; while in the case of C-6-gliomas the ratios were 5.58, 2.18, 3.96 and 3.02 for (99m)-Tc-CAP, (99)mTc(V)-DMSA, Tc-99m-Citrate and (TlCl)-Tl-201, respectively. (C) 2001 . .
URI: http://dx.doi.org/10.1016/S0969-8043(01)00113-0
http://dspace.library.iitb.ac.in/xmlui/handle/10054/10485
http://hdl.handle.net/10054/10485
ISSN: 0969-8043
Appears in Collections:Article

Files in This Item:

There are no files associated with this item.

View Statistics

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

 

Valid XHTML 1.0! DSpace Software Copyright © 2002-2010  Duraspace - Feedback