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Please use this identifier to cite or link to this item: http://dspace.library.iitb.ac.in/jspui/handle/10054/10307

Title: A dual mode of regulation of flgM by ScoC in Bacillus subtilis
Authors: KODGIRE, P
RAO, KK
Keywords: sigma(d)-dependent gene-expression
ribosome-binding site
anti-sigma factors
translational efficiency
mutations
upstream
motility
protein
operon
hpr
Issue Date: 2009
Publisher: NATL RESEARCH COUNCIL CANADA-N R C RESEARCH PRESS
Citation: CANADIAN JOURNAL OF MICROBIOLOGY, 55(8), 983-989
Abstract: In Bacillus subtilis, the transition state regulator ScoC indirectly, negatively regulates the anti-sigma(D) factor FlgM in a SinR-dependent pathway leading to an increased availability of sigma(D). In addition to the SinR-dependent pathway, ScoC negatively regulates FlgM via directly repressing flgM transcription by binding to two sites in the promoter region of the flgM operon. Our studies also show that the regulation of FlgM by SinR is not at the transcriptional or translational levels. Thus, ScoC shows a dual mode of downregulation of FlgM, via both SinR-dependent and -independent pathways, which eventually results in the increased sigma(D) activity.
URI: http://dx.doi.org/10.1139/W09-049
http://dspace.library.iitb.ac.in/xmlui/handle/10054/10307
http://hdl.handle.net/10054/10307
ISSN: 0008-4166
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