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| Title: | A new membrane probing steroidal spin label: Synthesis and applications |
| Authors: | KATOCH, R
TRIVEDI, GK
PHADKE, RS |
| Keywords: | model membranes
phase-transitions
lithocholic acid
biomembranes
nitroxides
2'-(3-alpha-benzyloxy-24-norcholan-23-yl)-2',4',4'-trimethyl-4',5'-dihydrooxazo.
permeability
cholesterol
chemistry
fluidity |
| Issue Date: | 2000 |
| Publisher: | NATL INST SCIENCE COMMUNICATION |
| Citation: | INDIAN JOURNAL OF BIOCHEMISTRY & BIOPHYSICS, 37(1), 45-50 |
| Abstract: | The applicability of a new steroidal spin label, 3-oxo-androstan-17 beta-yl-(2",2",6",6"-tetramethyl-N-oxyl) piperidyl butan-1',4'-dioate, in studying the phase transition properties of model membrane L-alpha-dipalmitoyl phosphatidyl choline (DPPC) in the presence and absence of drugs has been explored. Its synthesis and characterization has been described herein. Besides, the localization of this spin label in lipid liposomes has been studied using electron spin resonance (ESR), differential scanning calorimetry (DSC) and H-1 and P-31 NMR spectroscopic techniques. The label has also been used to study the permeability of epinephrine into membrane. The results show that the spin label has a good potential as a spin probe in the study of biomembranes. |
| URI: | http://dspace.library.iitb.ac.in/xmlui/handle/10054/10204
http://hdl.handle.net/10054/10204 |
| ISSN: | 0301-1208 |
| Appears in Collections: | Article
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