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Please use this identifier to cite or link to this item: http://dspace.library.iitb.ac.in/jspui/handle/100/3154

Title: Neurotransmission by atp: new insights, novel mechanisms
Authors: GHILDYAL, P
MANCHANDA, R
Issue Date: 2002
Publisher: NATL INST SCIENCE COMMUNICATION
Citation: INDIAN JOURNAL OF BIOCHEMISTRY & BIOPHYSICS,39(3)137-147
Abstract: Purines have long been known for their roles in extracellular signaling. One of the most interesting functions to come to light recently has been the involvement, particularly of adenosine 5'-triphosphate (ATP), as a neurotransmitter in the central and the sympathetic nervous system. ATP is stored in and released from synaptic nerve terminals, like other neurotransmitters, and is known to act post-synaptically via specific rapidly-conducting, ligand-gated ion channels, the P-2X receptors. Another interesting feature is the discovery that ATP is widely found to be a "co-transmitter" at the same synapses in combination with other neurotransmitters such as noradrenaline, acetylcholine, and GABA, altering our picture of the biophysics and biochemistry of neurotransmission at these synapses. We describe here these and other aspects of neurotransmission by ATP being investigated vigorously today, including recent findings on P-2X receptors and those on the synaptic inactivation of ATP by ecto-ATPase. We conclude by pointing out possible pharmacological and. clinical implications of neurotransmission by ATP.
URI: http://dspace.library.iitb.ac.in/xmlui/handle/10054/13962
http://hdl.handle.net/100/3154
ISSN: 0301-1208
Appears in Collections:Review

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