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Please use this identifier to cite or link to this item: http://dspace.library.iitb.ac.in/jspui/handle/100/3036

Title: Protein aggregation: a perspective from amyloid and inclusion-body formation
Authors: IDICULA-THOMAS, S
BALAJI, PV
Keywords: folding intermediates
molecular evolution
natively unfolded
protein folding
Issue Date: 2007
Publisher: CURRENT SCIENCE ASSN
Citation: CURRENT SCIENCE,92(6)758-767
Abstract: Over the past few decades, an overwhelmingly vast amount of research has been dedicated to understanding protein aggregation. This review summarizes the current understanding of protein aggregation from the viewpoint of its two important manifestations: formation of amyloid fibrils and inclusion bodies. The article summarizes the structure, mechanism of formation, predisposing factors and measures of overcoming inclusion body and amyloid formation. The protective role played by molecular evolution in curbing aggregation and results from recent studies on the prediction of aggregation rates based on primary structure have also been discussed.
URI: http://dspace.library.iitb.ac.in/xmlui/handle/10054/13798
http://hdl.handle.net/100/3036
ISSN: 0011-3891
Appears in Collections:Review

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