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Please use this identifier to cite or link to this item: http://dspace.library.iitb.ac.in/jspui/handle/100/3013

Title: Bacterial degradation of phthalate isomers and their esters
Authors: VAMSEE-KRISHNA, C
PHALE, PS
Keywords: phthalate esters
toxicity
biodegradation
dioxygenases
genetic regulation
Issue Date: 2008
Publisher: SPRINGER
Citation: INDIAN JOURNAL OF MICROBIOLOGY,48(1)19-34
Abstract: Phthalate isomers and their esters are used heavily in various industries. Excess use and leaching from the product pose them as major pollutants. These chemicals are toxic, teratogenic, mutagenic and carcinogenic in nature. Various aspects like toxicity, diversity in the aerobic bacterial degradation, enzymes and genetic organization of the metabolic pathways from various bacterial strains are reviewed here. Degradation of these esters proceeds by the action of esterases to form phthalate isomers, which are converted to dihydroxylated intermediates by specific and inducible phthalate isomer dioxygenases. Metabolic pathways of phthalate isomers converge at 3,4-dihydroxybenzoic acid, which undergoes either ortho-or meta-ring cleavage and subsequently metabolized to the central carbon pathway intermediates. The genes involved in the degradation are arranged in operons present either on plasmid or chromosome or both, and induced by specific phthalate isomer. Understanding metabolic pathways, diversity and their genetic regulation may help in constructing bacterial strains through genetic engineering approach for effective bioremediation and environmental clean up.
URI: http://dx.doi.org/10.1007/s12088-008-0003-8
http://dspace.library.iitb.ac.in/xmlui/handle/10054/13829
http://hdl.handle.net/100/3013
ISSN: 0046-8991
Appears in Collections:Review

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