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Please use this identifier to cite or link to this item: http://dspace.library.iitb.ac.in/jspui/handle/100/2994

Title: Targeting ftsz for antibacterial therapy: a promising avenue
Authors: KAPOOR, S
PANDA, D
Keywords: antibacterials
bacterial cytokinesis
drug-targets
ftsz
z-ring
Issue Date: 2009
Publisher: INFORMA HEALTHCARE
Citation: EXPERT OPINION ON THERAPEUTIC TARGETS,13(9)1037-1051
Abstract: The widespread problem of bacterial resistance towards existing drugs and the paucity of effective drugs for the treatment of bacterial infections have prompted the scientific community to think about novel strategies for discovering new classes of antibacterial drugs. Target-based screening of inhibitory molecules has emerged as an important alternative for the development of potent antibacterials. FtsZ is a prokaryotic cytoskeleton protein, which plays an important role in bacterial cell division. It forms a highly dynamic Z-ring at the centre of the cell and recruits other accessory proteins, which are involved in bacterial cytokinesis. Here, we discuss the assembly dynamics of FtsZ and the key features that place it among the novel antibacterial drug targets. The recent progress in finding the inhibitors of functional properties of FtsZ and its interactions with other proteins, which has been enabled by advanced screening methods and structure-based design, are presented herein. Although there are significant challenges in the development of this new class of antibacterial drugs, nonetheless the therapeutic potential of FtsZ as a drug target is motivating researchers to find lead molecules with enhanced efficacy and reduced toxicity.
URI: http://dx.doi.org/10.1517/14728220903173257
http://dspace.library.iitb.ac.in/xmlui/handle/10054/13760
http://hdl.handle.net/100/2994
ISSN: 1472-8222
Appears in Collections:Review

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