DSpace
 

DSpace at IIT Bombay >
IITB Publications >
Review >

Please use this identifier to cite or link to this item: http://dspace.library.iitb.ac.in/jspui/handle/100/2983

Title: Nanotechniques in proteomics: current status, promises and challenges
Authors: RAY, S
CHANDRA, H
SRIVASTAVA, S
Keywords: nanotechniques
proteomics
carbon nanotubes
quantum clots
gold nanoparticles
Issue Date: 2010
Publisher: ELSEVIER ADVANCED TECHNOLOGY
Citation: BIOSENSORS & BIOELECTRONICS,25(11)2389-2401
Abstract: Proteomics has witnessed rapid growth over the last decade, with increasing emphasis on development of robust and high-throughput technologies to understand the diverse proteome. Researchers have gone beyond traditional techniques and approached promising disciplines like nanotechnology to satisfy the growing demands of studying numerous complex and functional proteins. Applications of nanotechniques in proteomics have steadily been growing over the years and it has established itself as a technical platform for sensitive detection of low abundance proteins in shorter time. The main focus of this interdisciplinary approach is to increase the sensitivity and improve biocompatibility. The most promising candidates for nanoproteomics, namely carbon nanotubes and nanowires, quantum dots and nanoscopic gold particles, offer several advantages such as high sensitivity, real-time measurements and improved reproducibility. However, toxicity and biocompatibility issues for in vivo applicability require further exploration to provide a suitable risk-to-benefit assessment of these emerging nanotechniques. This article highlights the current status and key technological advances of nanotechniques that offer promising applications in proteomics and addresses their prospects, merits and challenges. (C) 2010 Elsevier B.V. All rights reserved.
URI: http://dx.doi.org/10.1016/j.bios.2010.04.010
http://dspace.library.iitb.ac.in/xmlui/handle/10054/13824
http://hdl.handle.net/100/2983
ISSN: 0956-5663
Appears in Collections:Review

Files in This Item:

There are no files associated with this item.

View Statistics

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

 

Valid XHTML 1.0! DSpace Software Copyright © 2002-2010  Duraspace - Feedback