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Please use this identifier to cite or link to this item: http://dspace.library.iitb.ac.in/jspui/handle/100/2972

Title: Type ii phosphatidylinositol 4-kinase(s) in cell signaling cascades
Authors: SINHA, RK
SUBRAHMANYAM, G
Keywords: lipid kinases
cell signaling
cytoskeleton
cell adhesion
microbial pathogenicity
Issue Date: 2007
Publisher: NATL INST SCIENCE COMMUNICATION
Citation: INDIAN JOURNAL OF BIOCHEMISTRY & BIOPHYSICS,44(5)289-294
Abstract: Phosphorylated derivatives of phosphatidylinositol (PtdIns) are key components of many signaling cascades. Many isoforms of PtdIns kinases, PtdIns phosphate kinases and phosphatases use these lipids in amazing networks of signaling cascades that are yet to be understood fully. PtdIns 4-kinase(s) phosphorylates PtdIns at the 4(th)-OH position of inositol head group and are classified in to type II and III PtdIns 4-kinases. While type III PtdIns 4-kinases are implicated in vesicular trafficking, type II PtdIns 4-kinases are suggested to play a role in cell signaling, cytoskeletal rearrangements, cell motility and in microbial pathogenicity. This paper reviews the role of type II PtdIns 4-kinases in cell signaling cascades in health and disease.
URI: http://dspace.library.iitb.ac.in/xmlui/handle/10054/13814
http://hdl.handle.net/100/2972
ISSN: 0301-1208
Appears in Collections:Review

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