DSpace
 

DSpace at IIT Bombay >
IITB Publications >
Proceedings papers >

Please use this identifier to cite or link to this item: http://dspace.library.iitb.ac.in/jspui/handle/100/2527

Title: Ferrite-Silica-Insulin nanocomposites (FeSINC) for glucose reduction
Authors: DWIVEDI, N
ARUNAGIRINATHAN, MA
SHARMA, S
BELLARE, J
Keywords: controlled drug-delivery
raman-spectroscopy
systems
carrier
Issue Date: 2008
Publisher: CRC PRESS-TAYLOR & FRANCIS GROUP
Citation: NSTI NANOTECH 2008, VOL 1, TECHNICAL PROCEEDINGS,770-773
Abstract: Proteins find more stable environment upon encapsulation in a silica host, because of polymeric silica frame that grows around the macromolecule and protects them from denaturation. Silica-insulin nanocomposite (SINC) and ferrite coated SINC (FeSINC) prepared by polyelectrolytic condensation of silica precursor on insulin were studied for their ability to control glucose levels. SINC was prepared by acid- base catalysed polymerization in presence of insulin at room temperature by modified Stober's process. FeSINC nanoparticles were prepared by co-precipitation of both ferric and ferrous salts on the bovine insulin loaded silica nanoparticle. The presence of ferrite coating in FeSINC was identified using VSM and quantified from XRF study. The intermolecular interactions in these nanocomposites were studied by FTIR and Raman spectroscopy. An in vivo study indicated that FeSINC was biologically active in reducing glucose levels as compared to SINC.
URI: http://dspace.library.iitb.ac.in/xmlui/handle/10054/15840
http://hdl.handle.net/100/2527
ISBN: 978-1-4200-8503-7
Appears in Collections:Proceedings papers

Files in This Item:

There are no files associated with this item.

View Statistics

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

 

Valid XHTML 1.0! DSpace Software Copyright © 2002-2010  Duraspace - Feedback