Please use this identifier to cite or link to this item: http://dspace.library.iitb.ac.in/xmlui/handle/100/17381
Title: Development of Unimolecular Tetrakis(piperidin-4-ol) as a Ligand for Suzuki-Miyaura Cross-Coupling Reactions: Synthesis of Incrustoporin and Preclamol
Authors: NALLASIVAM, JL
FERNANDES, RA
Keywords: Palladium-Catalyzed Reaction
Highly-Active Catalyst
Carbon Bond Formation
Aryl Chlorides
Selective Synthesis
Efficient Synthesis
Allylic Alcohols
Organic Halides
Scale Synthesis
C-N
Issue Date: 2015
Publisher: WILEY-V C H VERLAG GMBH
Citation: EUROPEAN JOURNAL OF ORGANIC CHEMISTRY(16)3558-3567
Abstract: A domino aza-Cope/aza-Prins cascade enabled the synthesis of a new class of 4-hydroxypiperidine-appended mono, bis, tris, and tetrakis unimolecular compounds that served as efficient ligands to catalyze Suzuki-Miyaura cross-coupling reactions under aerobic conditions. Various biaryls, terphenyls, and heterocyclic biphenyls were obtained in good to excellent yields. The ligands were also capable of catalyzing the Heck-Mizoroki reaction. As an application, the Suzuki-Miyaura coupling reaction was used in the synthesis of incrustoporin, its analogs, and the drug molecule preclamol.
URI: http://dx.doi.org/10.1002/ejoc.201500353
http://dspace.library.iitb.ac.in/jspui/handle/100/17381
ISSN: 1434-193X
1099-0690
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