Please use this identifier to cite or link to this item: http://dspace.library.iitb.ac.in/xmlui/handle/100/17265
Title: Synthesis and evaluation of 2-heteroaryl and 2,3-diheteroaryl-1,4-naphthoquinones that potently induce apoptosis in cancer cells
Authors: TANDON, VK
MAURYA, HK
KUMAR, S
RASHID, A
PANDA, D
Issue Date: 2014
Publisher: ROYAL SOC CHEMISTRY
Citation: RSC ADVANCES, 4(24)12441-12447
Abstract: This article describes the preparation of 2-heteroaryl and 2,3-diheteroaryl-1,4-naphthoquinones by an environmentally benign short synthetic route with the goal of finding 1,4-naphthoquinone derivatives that induce apoptosis in cancer cells. We have identified three most active naphthoquinones 10, 12 and 15 that potently induce apoptosis in human cervical carcinoma (HeLa) cells. One of these three compounds perturbed both microtubule and actin filaments.
URI: http://dx.doi.org/10.1039/c3ra47720g
http://dspace.library.iitb.ac.in/jspui/handle/100/17265
ISSN: 2046-2069
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