Please use this identifier to cite or link to this item: http://dspace.library.iitb.ac.in/xmlui/handle/100/16000
Title: Enantioselective Synthesis of alpha-Amino-gamma-sulfonyl Phosphonates with a Tetrasubstituted Chiral alpha-Carbon via Quinine-Squaramide-Catalyzed Michael Addition of Nitrophosphonates to Vinyl Sulfones
Authors: BERA, K
NAMBOOTHIRI, INN
Keywords: Amino Phosphonates
Amino Sulfones
Asymmetric Catalysis
Michael Addition
Squaramides
Issue Date: 2013
Publisher: WILEY-V C H VERLAG GMBH
Citation: ADVANCED SYNTHESIS & CATALYSIS, 355(7)1265-1270
Abstract: -Nitro--sulfonyl phosphonates with a key tetrasubstituted chiral -carbon center have been synthesized for the first time in high yield and enantioselectivity through a quinine-squaramide-catalyzed conjugate addition of -nitro phosphonates to aryl vinyl sulfones. Representative examples presented here for the transformation of nitrosulfonyl phosphonates to aminosulfonyl phosphonates, alkylation at the -position of the sulfonyl group followed by desulfonation and scale-up of the conjugate addition highlight the practical applications of the methodology.
URI: http://dx.doi.org/10.1002/adsc.201300224
http://dspace.library.iitb.ac.in/jspui/handle/100/16000
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