Please use this identifier to cite or link to this item:
|Title:||Enantioselective Synthesis of alpha-Amino-gamma-sulfonyl Phosphonates with a Tetrasubstituted Chiral alpha-Carbon via Quinine-Squaramide-Catalyzed Michael Addition of Nitrophosphonates to Vinyl Sulfones|
|Publisher:||WILEY-V C H VERLAG GMBH|
|Citation:||ADVANCED SYNTHESIS & CATALYSIS, 355(7)1265-1270|
|Abstract:||-Nitro--sulfonyl phosphonates with a key tetrasubstituted chiral -carbon center have been synthesized for the first time in high yield and enantioselectivity through a quinine-squaramide-catalyzed conjugate addition of -nitro phosphonates to aryl vinyl sulfones. Representative examples presented here for the transformation of nitrosulfonyl phosphonates to aminosulfonyl phosphonates, alkylation at the -position of the sulfonyl group followed by desulfonation and scale-up of the conjugate addition highlight the practical applications of the methodology.|
|Appears in Collections:||Article|
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.