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Title: Triazole linked lower rim glycosyl appended 1,3-calix[4]arene conjugates: Synthesis, characterization, and their interaction with jacalin
Authors: CHINTA, JP
Keywords: Calix[4]Arene Glyco Conjugates
1,3-Dipolar Addition
Trp Recognition
Interaction Of Conjugates With Jacalin
Fluorescence And Circular Dichroism
Issue Date: 2013
Abstract: Triazole linked lower rim galactosyl and lactosyl appended calix[4]arene conjugates have been synthesized by 1,3 dipolar addition of glycosyl azide and calix[4]arene alkyne. All these conjugates were characterized by H-1 and C-13 NMR, IR and mass spectrometry. Interaction of amino acids with the galactosyl conjugate of calix[4]arene (5) was studied using absorption and H-1 NMR techniques. Absorption studies showed that Trp interacts with triazole ring of 5. This was further confirmed by H-1 NMR study which showed an upfield shift in the triazole proton of 5 upon titrating with Trp. The preliminary studies of interaction of these conjugates with Jacalin were demonstrated by fluorescence and circular dichroism (CD) spectroscopy techniques. (C) 2012 Elsevier Ltd. All rights reserved.
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