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Please use this identifier to cite or link to this item: http://dspace.library.iitb.ac.in/jspui/handle/100/14262

Title: Regioselective Synthesis of Sulfonylpyrazoles via Base Mediated Reaction of Diazosulfones with Nitroalkenes and a Facile Entry into Withasomnine
Authors: KUMAR, R
NAMBOOTHIRI, INN
Keywords: BESTMANN-OHIRA REAGENT
BAYLIS-HILLMAN ADDUCTS
ONE-STEP SYNTHESIS
VINYL SULFONES
INTRAMOLECULAR CYCLOPROPANATION
ASYMMETRIC CATALYSIS
RADICAL CYCLIZATION
BIOLOGICAL-ACTIVITY
PYRAZOLE ALKALOIDS
CHEMISTRY
Issue Date: 2011
Publisher: AMER CHEMICAL SOC
Citation: ORGANIC LETTERS,13(15)4016-4019
Abstract: A base mediated reaction of alpha-diazo-beta-ketosulfone with nitroalkenes affords sulfonylpyrazoles as single regioisomers in excellent yield in a one-pot room temperature reaction. Aryl, heteroaryl, styrenyl, alkyl, hydroxymethyl, and hydrazinyl groups could be introduced on the pyrazole ring by the appropriate choice of nitroalkenes. Synthesis of sulfonylpyrazole fused to other heterocycles and application of the methodology to an expedient synthesis of a pyrazole alkaloid, Withasomnine, are also reported.
URI: http://dx.doi.org/10.1021/ol2015341
http://dspace.library.iitb.ac.in/jspui/handle/100/14262
ISSN: 1523-7060
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