Please use this identifier to cite or link to this item: http://dspace.library.iitb.ac.in/xmlui/handle/100/14210
Title: Strained dimethyl 2-(bromoselanyl)-5-tert-butylisophthalate: a reactive precursor for the synthesis of ebselen analogs
Authors: SELVAKUMAR, K
SINGH, HB
BUTCHER, RJ
Keywords: Active Organoselenium Compound
Thyroid-Hormone Synthesis
Peroxidase-Like Activity
Glutathione-Peroxidase
Antioxidant Activity
Antithyroid Drugs
Crystal-Structure
Selenium
Derivatives
Heterocycles
Issue Date: 2011
Publisher: PERGAMON-ELSEVIER SCIENCE LTD
Citation: TETRAHEDRON LETTERS,52(50)6831-6834
Abstract: A facile synthesis of ebselen analogs, having Se...O(ester) secondary bonding interaction, is described. The reaction of dimethyl 2-(bromoselanyl)-5-tert-butylisophthalate (4) with different diprotic amines such as ethanolamine, 2-chloroethylamine, and N,N'-dimethylethylenediamine afforded the ebselen analogs. Reaction of 4 with ethylenediamine and tris(2-aminoethyl)amine resulted in the formation of bis-and tris-ebselen derivatives, respectively.(C) 2011 Elsevier Ltd. All rights reserved.
URI: http://dx.doi.org/10.1016/j.tetlet.2011.10.067
http://dspace.library.iitb.ac.in/jspui/handle/100/14210
ISSN: 0040-4039
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