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| Title: | Strained dimethyl 2-(bromoselanyl)-5-tert-butylisophthalate: a reactive precursor for the synthesis of ebselen analogs |
| Authors: | SELVAKUMAR, K
SINGH, HB
BUTCHER, RJ |
| Keywords: | ACTIVE ORGANOSELENIUM COMPOUND
THYROID-HORMONE SYNTHESIS
PEROXIDASE-LIKE ACTIVITY
GLUTATHIONE-PEROXIDASE
ANTIOXIDANT ACTIVITY
ANTITHYROID DRUGS
CRYSTAL-STRUCTURE
SELENIUM
DERIVATIVES
HETEROCYCLES |
| Issue Date: | 2011 |
| Publisher: | PERGAMON-ELSEVIER SCIENCE LTD |
| Citation: | TETRAHEDRON LETTERS,52(50)6831-6834 |
| Abstract: | A facile synthesis of ebselen analogs, having Se...O(ester) secondary bonding interaction, is described. The reaction of dimethyl 2-(bromoselanyl)-5-tert-butylisophthalate (4) with different diprotic amines such as ethanolamine, 2-chloroethylamine, and N,N'-dimethylethylenediamine afforded the ebselen analogs. Reaction of 4 with ethylenediamine and tris(2-aminoethyl)amine resulted in the formation of bis-and tris-ebselen derivatives, respectively.(C) 2011 Elsevier Ltd. All rights reserved. |
| URI: | http://dx.doi.org/10.1016/j.tetlet.2011.10.067
http://dspace.library.iitb.ac.in/jspui/handle/100/14210 |
| ISSN: | 0040-4039 |
| Appears in Collections: | Article
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