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Please use this identifier to cite or link to this item: http://dspace.library.iitb.ac.in/jspui/handle/100/14008

Title: Multifunctional alginate microspheres for biosensing, drug delivery and magnetic resonance imaging
Authors: JOSHI, A
SOLANKI, S
CHAUDHARI, R
BAHADUR, D
ASLAM, M
SRIVASTAVA, R
Keywords: IRON-OXIDE NANOPARTICLES
IN-VIVO EVALUATION
RECOMBINANT CELLS
GLUCOSE-OXIDASE
ENCAPSULATION
PARTICLES
FE3O4
ASSAY
DEXAMETHASONE
MEMBRANE
Issue Date: 2011
Publisher: ELSEVIER SCI LTD
Citation: ACTA BIOMATERIALIA,7(11)3955-3963
Abstract: This research aims to develop and investigate a multifunctional implantable system capable of biosensing, drug delivery and magnetic resonance imaging (MRI) for continuous monitoring, controlled anti-inflammatory drug delivery and imaging, respectively. A glucose biosensor, diclofenac sodium (Diclo) and magnetic nanoparticles (MNP) were used as the biosensor component, anti-inflammatory agent and MRI contrast agent, respectively. MNP were synthesized by the co-precipitation technique and loaded with the sensor and drug components into alginate microspheres using a commercial droplet generator. The multifunctional system was then characterized using optical microscopy, scanning electron microscopy, transmission electron microscopy, X-ray diffraction, vibrating sample magnetometry (VSM) and MRI. The MNP were found to be in the size range of 5-15 nm. The final system, comprising the biosensor, drug and MNP loaded inside alginate microspheres, was found to be in the size range of 10-60 mu m. Biosensing studies indicated an excellent glucose response curve, with a regression coefficient of 0.974 (0-10 mM of glucose, response time: 4 min). In vitro Diclo release shows that MNP loading in alginate microspheres increases the burst release percentage by 11-12% in both 60 and 10 pm particles. However, the duration of release for 85% drug release decreases with MNP loading by 7 and 6 days for 39 the 60 and 10 pm particles, respectively. Super-paramagnetism was confirmed by VSM, with 2.09 and 1.368 emu g(-1), respectively, for the 60 and 10 pm particles, with no hysteresis. MRI showed significant contrast for both sizes. The particles showed an excellent biocompatibility (>80%) for all combinations of formulations. The system shows a great potential for biosensing with concurrent drug delivery and visualization for biomedical applications. (C) 2011 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
URI: http://dx.doi.org/10.1016/j.actbio.2011.06.053
http://dspace.library.iitb.ac.in/jspui/handle/100/14008
ISSN: 1742-7061
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