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| Title: | Synthesis of Maradolipid |
| Authors: | SARPE, VA
KULKARNI, SS |
| Keywords: | ONE-POT PROTECTION
CORD-FACTOR ANALOGS
6,6'-DI-O-ACYLATED ALPHA,ALPHA-TREHALOSES
MYCOBACTERIUM-TUBERCULOSIS
DESICCATION RESISTANCE
TREHALOSE GLYCOLIPIDS
SCALE SYNTHESIS
DERIVATIVES
EFFICIENT
ALBUMIN |
| Issue Date: | 2011 |
| Publisher: | AMER CHEMICAL SOC |
| Citation: | JOURNAL OF ORGANIC CHEMISTRY,76(16)6866-6870 |
| Abstract: | The first synthesis of maradolipid, a unique dissymmetrically 6,6'-di-O-acylated trehalose glycolipid isolated from C. elegans, is accomplished in five steps starting from trehalose in 45% overall yield. The short synthesis relies on dissymmetrization of trehalose core via regioselective acylation of a 2,3,4,2',3',4'-hexa-O-TMS trehalose 6,6'-diol derivative as a key step. |
| URI: | http://dx.doi.org/10.1021/jo200979n
http://dspace.library.iitb.ac.in/jspui/handle/100/13871 |
| ISSN: | 0022-3263 |
| Appears in Collections: | Article
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