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Please use this identifier to cite or link to this item: http://dspace.library.iitb.ac.in/jspui/handle/100/13798

Title: Development of citrate-stabilized Fe(3)O(4) nanoparticles: Conjugation and release of doxorubicin for therapeutic applications
Authors: NIGAM, S
BARICK, KC
BAHADUR, D
Keywords: nanoparticle
iron oxide
surface functionalization
drug release
hyperthermia
iron-oxide nanoparticles
magnetite nanoparticles
fluorescence spectroscopy
model membranes
citric-acid
binding
phospholipids
particles
liposomes
transport
Issue Date: 2011
Publisher: ELSEVIER SCIENCE BV
Citation: JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS,323(2)237-243
Abstract: We demonstrate a single-step facile approach for the fabrication of citric acid functionalized (citrate-stabilized) Fe(3)O(4) aqueous colloidal magnetic nanoparticles (CA-MNP) of size 8-10 nm using soft chemical route. The surface functionalization of Fe(3)O(4) nanoparticles with citric acid was evident from infrared spectroscopy, thermal and elemental analyses, and zeta-potential measurements. The drug-loading efficiency of CA-MNP was investigated using doxorubicin hydrochloride (DOX) as a model drug to evaluate their potential as a carrier system. The quenching of fluorescence intensity and decrease in surface charge of drug loaded CA-MNP strongly suggest the interaction/attachment of drug molecules with CA-MNP. More specifically, the present investigation discusses a method for entrapping positively charged drugs on to the surface of negatively charged CA-MNP through electrostatic interactionsandsuggeststhatbounddrugmoleculeswillbereleasedinappreciableamountsinthe mild acidic environments of the tumors. Furthermore, the aqueous colloidal stability, optimal magnetization, good specific absorption rate (under external AC magnetic field) and cytocompatibility with cells suggested that CA-MNP is appropriate candidate for biomedical applications. (C) 2010 Elsevier B.V. All rights reserved.
URI: http://dx.doi.org/10.1016/j.jmmm.2010.09.009
http://hdl.handle.net/100/13798
ISSN: 0304-8853
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